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Supplementation Research
Aging & Longevity
Hormonal & Menopause Health
Inflammation & Immunity
Metabolic Health
General Preventive Health
Nutrition & Diet
Cardiovascular Health
Bone Health

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There are 178 published clinical (human) studies on K2 according to a Pubmed search. Many of them are sponsored and published by academia bodies, not private companies.
The results of these studies are copyrighted, however quoting small sections that are directly relevant to something one is writing about is acceptable under Fair Use, as long as one provides an appropriate citation. Summarizing and quoting from a medical article in a news article (Commentary, Criticism, “transformative” purpose) is considered a fair use according to this source. All human clinical studies were designed and performed on Menaquinone-7 chemical compound which does not differ in terms of bioavailability or safety profile regardless if obtained through organic synthesis or biochemistry (industrial fermentation). Vitamin K2 offered in the market differs only in terms of purity offered and presentation oil, powder, microcapsule. We encourage all our clients to produce educational content based on the available study results and fair use policy. In case of advertising of a specific brand, use of third-party study results is prohibited.
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TITLE
Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial.
AUTHORS
Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJ
SPONSORS
RWTH Aachen University
CATEGORY
Cardiovascular Health
DATE
Feb 2012
KEYWORDS
menaquinone-7 vascular calcification vitamin K deficiency vitamin K2
PUBMED LINK
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Link
TITLE
Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation.
AUTHORS
Bruge F, Bacchetti T, Principi F, Littarru GP, Tiano L
SPONSORS
Athenaeum Funds
CATEGORY
Bone Health
DATE
Oct 2011
KEYWORDS
menaquinone-7 olive oil vitamin K2
PUBMED LINK
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Link
TITLE
Vitamin K2 supplementation improves insulin sensitivity via osteocalcin metabolism: a placebo-controlled trial
AUTHORS
Hyung Jin Choi, Juyoun Yu, Hosanna Choi, Jee Hyun An, Sang Wan Kim, Kyong Soo Park, Hak C Jang, Seong Yeon Kim, Chan Soo Shin
SPONSORS
-
CATEGORY
Bone Health
DATE
Sep 2011
KEYWORDS
PUBMED LINK
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Link
TITLE
Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 (menatetrenone) among postmenopausal Thai women
AUTHORS
Thawee Songpatanasilp, La-or Chailurkit, Suwannee Chantprasertyothin, Boonsong Ongphiphadhanakul, Nimit Taechakraichana
SPONSORS
Thai Osteoporosis Foundation (TOPF); Eisai (Thailand) Marketing
CATEGORY
Bone Health
DATE
Sep 2011
KEYWORDS
GGCX gene Under-carboxylated osteocalcin Bone turnover markers Menatetrenone Postmenopausal Thai women
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
AUTHORS
Haruhiko Yoshida, Yasushi Shiratori, Masatoshi Kudo, Shuichiro Shiina, Toshihiko Mizuta, Masamichi Kojiro, Kyosuke Yamamoto, Yukihiro Koike, Kenichi Saito, Nozomu Koyanagi, Takao Kawabe, Seiji Kawazoe, Haruhiko Kobashi, Hiroshi Kasugai, Yukio Osaki, Yasuyuki Araki, Namiki Izumi, Hiroko Oka, Kunihiko Tsuji, Joji Toyota, Toshihito Seki, Toshiya Osawa, Naohiko Masaki, Masao Ichinose, Masataka Seike, Akihisa Ishikawa, Yoshiyuki Ueno, Kazumi Tagawa, Ryoko Kuromatsu, Shotaro Sakisaka, Hiroshi Ikeda, Hidekatsu Kuroda, Hiroyuki Kokuryu, Tatsuya Yamashita, Isao Sakaida, Tetsuo Katamoto, Kentaro Kikuchi, Minoru Nomoto, Masao Omata
SPONSORS
Eisai Co., Ltd
CATEGORY
General Preventive Health
DATE
Aug 2011
KEYWORDS
PUBMED LINK
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Link
TITLE
Doctor initiated clinical trial for obtaining evidences in treatment of osteoporosis: JOINT (Japanese Osteoporosis Intervention Trial) protocol
AUTHORS
Masataka Shiraki
SPONSORS
-
CATEGORY
Bone Health
DATE
Jul 2011
KEYWORDS
PUBMED LINK
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Link
TITLE
Possible site-specific effect of an intervention combining nutrition and lifestyle counselling with consumption of fortified dairy products on bone mass: the Postmenopausal Health Study II.
AUTHORS
Moschonis G, Kanellakis S, Papaioannou N, Schaafsma A, Manios Y
SPONSORS
FrieslandCampina B
CATEGORY
Hormonal & Menopause Health
DATE
Jul 2011
KEYWORDS
bone mineral density calcium menaquinone-7 phylloquinone postmenopausal women vitamin D3 vitamin K1 vitamin K2
PUBMED LINK
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Link
TITLE
Modelling the atypical absorption of menatetrenone and the metabolism to its epoxide: effect of VKORC1 polymorphism
AUTHORS
I H Baek, W Kang, H Y Yun, S S Lee, K I Kwon
SPONSORS
Chungnam National University
CATEGORY
General Preventive Health
DATE
Jun 2011
KEYWORDS
genetic variations, menatetrenone, menatetrenone epoxide, VKORC1
PUBMED LINK
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Link
TITLE
A comparative effectiveness study of bone density changes in women over 40 following three bone health plans containing variations of the same novel plant-sourced calcium
AUTHORS
Gilbert R Kaats, Harry G Preuss, Harry A Croft, Samuel C Keith, Patti L Keith
SPONSORS
-
CATEGORY
Bone Health
DATE
Mar 2011
KEYWORDS
bone mineral density; bone-health supplement; women over-40
PUBMED LINK
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Link
TITLE
Vitamin K2 supplementation does not influence bone loss in early menopausal women: a randomised double-blind placebo-controlled trial.
AUTHORS
Emaus N, Gjesdal CG, Almas B, Christensen M, Grimsgaard AS, Berntsen GK, Salomonsen L, Fonnebo V
SPONSORS
Norwegian Osteoporosis Association; Northern Norway Regional Health Authorities; NATURAL; Eckboe’s legacy
CATEGORY
Hormonal & Menopause Health
DATE
Oct 2010
KEYWORDS
"bone loss early menopausal women menaquinone-7 vitamin K2"
PUBMED LINK
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Link
TITLE
Multicenter phase II trial of vitamin K(2) monotherapy and vitamin K(2) plus 1alpha-hydroxyvitamin D(3) combination therapy for low-risk myelodysplastic syndromes
AUTHORS
Nobu Akiyama, Keisuke Miyazawa, Yoshinobu Kanda, Kaoru Tohyama, Mitsuhiro Omine, Kinuko Mitani, Kazuma Ohyashiki
SPONSORS
Esai Co., Ltd. (Tokyo, Japan); Chugai Pharmaceutical Co., Ltd. (Tokyo, Japan); Ministry of Health, Welfare and Labor of Japan
CATEGORY
General Preventive Health
DATE
Sep 2010
KEYWORDS
"Myelodysplastic syndromes Vitamin K2 Vitamin D3"
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis
AUTHORS
Kazuo Kojima, Masaya Tamano, Takashi Akima, Takashi Hashimoto, Toru Kuniyoshi, Chizu Maeda, Yuichi Majima, Koji Kusano, Toshimitu Murohisa, Makoto Iijima, Hideyuki Hiraishi
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Sep 2010
KEYWORDS
PUBMED LINK
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Link
TITLE
Dietary vitamin K2 supplement improves bone status after lung and heart transplantation
AUTHORS
Liv Forli, Jens Bollerslev, Svein Simonsen, Gunhild A Isaksen, Kari E Kvamsdal, Kristin Godang, Gaut Gadeholt, Are H Pripp, Oystein Bjortuft
SPONSORS
NattoPharma ASA; The Norwegian Foundation for Health and Rehabilitation
CATEGORY
Bone Health
DATE
Feb 2010
KEYWORDS
Vitamin K, Bone mineral density, Lung transplantation, Heart transplantation
PUBMED LINK
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Link
TITLE
The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children.
AUTHORS
van Summeren MJ, Braam LA, Lilien MR, Schurgers LJ, Kuis W, Vermeer C
SPONSORS
NattoPharma ASA; the Research Fund of the Wilhelmina Children’s Hospital (University Medical Centre (UMC) Utrecht).
CATEGORY
Bone Health
DATE
Oct 2009
KEYWORDS
"bone health menaquinone-7 vitamin K2"
PUBMED LINK
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Link
TITLE
Vitamin K to prevent fractures in older women: systematic review and economic evaluation
AUTHORS
M Stevenson, M Lloyd-Jones, D Papaioannou
SPONSORS
Health Technology Assessment programme
CATEGORY
Bone Health
DATE
Sep 2009
KEYWORDS
PUBMED LINK
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Link
TITLE
Highly recommended dose of MK4 for osteoporosis
AUTHORS
Narong Bunyaratavej, Nipat Kittimanon, Thunchanok Jitivirai, Boonsom Tongthongthip
SPONSORS
-
CATEGORY
Bone Health
DATE
Sep 2009
KEYWORDS
PUBMED LINK
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Link
TITLE
Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma
AUTHORS
Hitoshi Yoshiji, Ryuichi Noguchi, Masahisa Toyohara, Yasuhide Ikenaka, Mitsuteru Kitade, Kosuke Kaji, Masaharu Yamazaki, Junichi Yamao, Akira Mitoro, Masayoshi Sawai, Motoyuki Yoshida, Masao Fujimoto, Tatsuhiro Tsujimoto, Hideto Kawaratani, Masahito Uemura, Hiroshi Fukui
SPONSORS
no funding
CATEGORY
Cardiovascular Health
DATE
Aug 2009
KEYWORDS
Angiogenesis; Angiotensin-converting enzyme inhibitor; Hepatocellular carcinoma; Vascular endothelial growth factor; Vitamin K2
PUBMED LINK
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Link
TITLE
Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women.
AUTHORS
Binkley N, Harke J, Krueger D, Engelke J, Vallarta-Ast N, Gemar D, Checovich M, Chappell R, Suttie J
SPONSORS
Eisai; Roche Vitamins; Mission Pharmacal
CATEGORY
Hormonal & Menopause Health
DATE
Jun 2009
KEYWORDS
bone health menaquinone-4 phylloquinone postmenopausal women vitamin K1 vitamin K2
PUBMED LINK
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Link
TITLE
Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.
AUTHORS
Koitaya N, Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y
SPONSORS
-
CATEGORY
Hormonal & Menopause Health
DATE
Feb 2009
KEYWORDS
bone metabolism menaquinone-4 postmenopausal women vitamin K2
PUBMED LINK
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Link
TITLE
Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial
AUTHORS
Angela M Cheung Lianne Tile, Yuna Lee, George Tomlinson, Gillian Hawker, Judy Scher, Hanxian Hu, Reinhold Vieth, Lilian Thompson, Sophie Jamal, Robert Josse
SPONSORS
University Health Network, Toronto
CATEGORY
Supplementation Research
DATE
Oct 2008
KEYWORDS
PUBMED LINK
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Link
TITLE
Osteoclast inhibitory effects of vitamin K2 alone or in combination with etidronate or risedronate in patients with rheumatoid arthritis: 2-year results
AUTHORS
Minoru Morishita, Masakazu Nagashima, Koichi Wauke, Hiroshi Takahashi, Kenji Takenouchi
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Mar 2008
KEYWORDS
rheumatoid arthritis vitamin k2 etidronate risedronate receptor activator of nuclear factor-κb ligand osteoprotegerin
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma
AUTHORS
Naoki Hotta, Minoru Ayada, Ken Sato, Tetsuya Ishikawa, Akihiho Okumura, Eiji Matsumoto, Tomohiko Ohashi, Shinichi Kakumu
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Oct 2007
KEYWORDS
PUBMED LINK
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Link
TITLE
Comparative studies on effect of risedronate and alfacalcidol against glucocorticoid-induced osteoporosis in rheumatoid arthritic patients
AUTHORS
Shigeki Yamada, Hideki Takagi, Hiroki Tsuchiya, Takako Nakajima, Hiroaki Ochiai, Ayumi Ichimura, Hisashi Iwata, Takanobu Toriyama
SPONSORS
-
CATEGORY
Bone Health
DATE
Sep 2007
KEYWORDS
osteoporosis, rheumatoid arthritis, risedronate, vitamin D3, bone mineral density
PUBMED LINK
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Link
TITLE
Excretion of the urinary 5C- and 7C-aglycone metabolites of vitamin K by young adults responds to changes in dietary phylloquinone and dihydrophylloquinone intakes.
AUTHORS
Harrington DJ, Booth SL, Card DJ, Shearer MJ
SPONSORS
-
CATEGORY
Nutrition & Diet
DATE
Jul 2007
KEYWORDS
phylloquinone urinary excretion of vitamin K metabolites vitamin K1
PUBMED LINK
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Link
TITLE
Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
AUTHORS
M H J Knapen, L J Schurgers, C Vermeer
SPONSORS
EISAI Co. Ltd. (Tokyo, Japan)
CATEGORY
Bone Health
DATE
Jul 2007
KEYWORDS
Bone mineral content, Femoral neck strength, Fracture risk, Menaquinone, Osteoporosis, Vitamin K
PUBMED LINK
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Link
TITLE
Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection
AUTHORS
Satoru Kakizaki, Naondo Sohara, Ken Sato, Hideyuki Suzuki, Masatoshi Yanagisawa, Hiroaki Nakajima, Hitoshi Takagi, Atsushi Naganuma, Toshiyuki Otsuka, Hitomi Takahashi, Tetsuya Hamada, Masatomo Mori
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Apr 2007
KEYWORDS
chemoprevention, hepatocellular carcinoma, menatetrenone, vitamin K2
PUBMED LINK
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Link
TITLE
Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7.
AUTHORS
Schurgers LJ, Teunissen KJ, Hamulyak K, Knapen MH, Vik H, Vermeer C
SPONSORS
Natural ASA, Lysaker, Norway (C.V.)
CATEGORY
Nutrition & Diet
DATE
Apr 2007
KEYWORDS
menaquinone-7 phylloquinone vitamin K1 vitamin K2 vitamin absorption
PUBMED LINK
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Link
TITLE
Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population
AUTHORS
Rina Kimura, Yoshihiro Kokubo, Kotaro Miyashita, Ryoichi Otsubo, Kazuyuki Nagatsuka, Toshiho Otsuki, Toshiyuki Sakata, Junko Nagura, Akira Okayama, Kazuo Minematsu, Hiroaki Naritomi, Shigenori Honda, Kiyoshi Sato, Hitonobu Tomoike, Toshiyuki Miyata
SPONSORS
Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO) of Japan; Ministry of Health, Labor, and Welfare of Japan; Ministry of Education, Culture, Sports, Science, and Technology of Japan
CATEGORY
General Preventive Health
DATE
Dec 2006
KEYWORDS
PUBMED LINK
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Link
TITLE
Treatment of natto, a fermented soybean preparation, to prevent excessive plasma vitamin K concentrations in patients taking warfarin.
AUTHORS
Homma K, Wakana N, Suzuki Y, Nukui M, Daimatsu T, Tanaka E, Tanaka K, Koga Y, Nakajima Y, Nakazawa H
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Oct 2006
KEYWORDS
menaquinone-7 natto plasma concentration of vitamin K vitamin K2 warfarin
PUBMED LINK
open link icon
Link
TITLE
Effect of vitamin K2 treatment on carboxylation of osteocalcin in early postmenopausal women
AUTHORS
Toshiyuki Yasui, Yuka Miyatani, Junko Tomita, Masayo Yamada, Hirokazu Uemura, Masakazu Miura, Minoru Irahara
SPONSORS
-
CATEGORY
Bone Health
DATE
Aug 2006
KEYWORDS
Vitamin K, bone health, undercarboxylated osteocalcin, early postmenopause
PUBMED LINK
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Link
TITLE
Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials
AUTHORS
Sarah Cockayne, Joy Adamson, Susan Lanham-New, Martin J Shearer, Simon Gilbody, David J Torgerson
SPONSORS
no funding
CATEGORY
Bone Health
DATE
Jun 2006
KEYWORDS
vitamin K1, vitamin K2, vitamin K3, phylloquinone, Konakion, phytonadione, menadione, menaquinone, phytomenadione, and Mephyton
PUBMED LINK
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Link
TITLE
Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia
AUTHORS
Yuditiya Purwosunu, Muharram, Ichramsyah A Rachman, Soelarto Reksoprodjo, Akihiko Sekizawa
SPONSORS
Eisai (Tokyo, Japan)
CATEGORY
Hormonal & Menopause Health
DATE
Apr 2006
KEYWORDS
bone mineral density, menatetrenone, osteocalcin, osteoporosis, postmenopause
PUBMED LINK
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Link
TITLE
The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study
AUTHORS
Toshihiko Mizuta, Iwata Ozaki, Yuichiro Eguchi, Tsutomu Yasutake, Seiji Kawazoe, Kazuma Fujimoto, Kyosuke Yamamoto
SPONSORS
Intractable Hepatitis Study Group of Japan awarded to K.Y
CATEGORY
General Preventive Health
DATE
Feb 2006
KEYWORDS
clinical trial, liver carcinoma, vitamin K, chemoprevention
PUBMED LINK
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Link
TITLE
A head-to-head comparative study for evaluation of effectiveness among drugs for osteoporosis
AUTHORS
Masataka Shiraki
SPONSORS
-
CATEGORY
Bone Health
DATE
Jan 2006
KEYWORDS
PUBMED LINK
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Link
TITLE
Promotion of bone formation by fermented soybean (Natto) intake in premenopausal women
AUTHORS
Hironobu Katsuyama, Seiji Ideguchi, Masao Fukunaga, Tatsushige Fukunaga, Kiyofumi Saijoh, Shigeo Sunami
SPONSORS
Ministry of Education, Science, Sports, Culture and Technology of Japan; Kawasaki Medical School
CATEGORY
Hormonal & Menopause Health
DATE
Apr 2004
KEYWORDS
premenopausal women , Natto intake, stiffness index, bone formation marker, vitamin K2
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 and estrogen administration on bone formation
AUTHORS
Kohzo Aisaka
SPONSORS
-
CATEGORY
Bone Health
DATE
Feb 2004
KEYWORDS
PUBMED LINK
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Link
TITLE
Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine
AUTHORS
Katsuhiko Yonemura, Hirotaka Fukasawa, Yoshihide Fujigaki, Akira Hishida
SPONSORS
-
CATEGORY
Bone Health
DATE
Jan 2004
KEYWORDS
Osteoporosis; prednisolone; vitamin D; vitamin K
PUBMED LINK
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Link
TITLE
Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa
AUTHORS
Toshiya Iketani, Nobuo Kiriike, Murray, B Stein, Kouji Nagao, Toshihiko Nagata, Naomitsu Minamikawa, Atsushi Shidao, Hidehiro Fukuhara
SPONSORS
-
CATEGORY
Bone Health
DATE
Mar 2003
KEYWORDS
Eating disorder; Osteoporosis; Treatment; Bone metabolism marker
PUBMED LINK
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Link
TITLE
Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis.
AUTHORS
Miki T, Nakatsuka K, Naka H, Kitatani K, Saito S, Masaki H, Tomiyoshi Y, Morii H, Nishizawa Y
SPONSORS
-
CATEGORY
Bone Health
DATE
Jan 2003
KEYWORDS
bone metabolism calcium menaquinone-4 osteoporosis vitamin K2
PUBMED LINK
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Link
TITLE
Improvement of vitamin K status of breastfeeding infants with maternal supplement of vitamin K2 (MK40)
AUTHORS
Tomizo Nishiguchi, Miwa Yamashita, Makoto Maeda, Kaoru Matsuyama, Takao Kobayashi, Naohiro Kanayama, Toshihiko Terao
SPONSORS
-
CATEGORY
Supplementation Research
DATE
Dec 2002
KEYWORDS
PIVKA-ll, breast milk, vitamin K, menaquinone 4 (MK4), hepaplastin test (HPT)
PUBMED LINK
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Link
TITLE
Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients
AUTHORS
T Sugimoto, M Yamakado, K Matsushita, T Iwamoto, H Tagawa
SPONSORS
-
CATEGORY
Bone Health
DATE
Nov 2002
KEYWORDS
menatetrenone; vitamin k; bone mineral density; continuous ambulatory peritoneal dialysis (capd); pharmacodynamics
PUBMED LINK
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Link
TITLE
Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver
AUTHORS
Susumu Shiomi, Shuhei Nishiguchi, Shoji Kubo, Akihiro Tamori, Daiki Habu, Tadashi Takeda, Hironobu Ochi
SPONSORS
-
CATEGORY
Bone Health
DATE
Apr 2002
KEYWORDS
PUBMED LINK
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Link
TITLE
Effect of continuous combined therapy with vitamin K(2) and vitamin D(3) on bone mineral density and coagulofibrinolysis function in postmenopausal women
AUTHORS
Takahisa Ushiroyama, Atushi Ikeda, Minoru Ueki
SPONSORS
Eizai Pharmaceutical Co Ltd
CATEGORY
Bone Health
DATE
Mar 2002
KEYWORDS
Vitamin K2; Vitamin D3; Bone mineral density; Postmenopause; Coagulofibrinolysis
PUBMED LINK
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Link
TITLE
Menaquinone-4 in breast milk is derived from dietary phylloquinone.
AUTHORS
Thijssen HH, Drittij MJ, Vermeer C, Schoffelen E
SPONSORS
-
CATEGORY
Nutrition & Diet
DATE
Mar 2002
KEYWORDS
menaquinone-4 phylloquinone vitamin K1 vitamin K2
PUBMED LINK
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Link
TITLE
Menatetrenone, a vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome
AUTHORS
A Takami, H Asakura, S Nakao
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Jan 2002
KEYWORDS
Vitamin K2 · Menatetrenone · Myelodysplastic syndrome · Refractory anemia
PUBMED LINK
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Link
TITLE
Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency.
AUTHORS
Asakura H, Myou S, Ontachi Y, Mizutani T, Kato M, Saito M, Morishita E, Yamazaki M, Nakao S
SPONSORS
-
CATEGORY
Bone Health
DATE
Dec 2001
KEYWORDS
"hemostatic balance menaquinone-4 osteoporosis vitamin K2"
PUBMED LINK
open link icon
Link
TITLE
Efficacy and safety of Menatetrenone-4 postmenopausal Thai women
AUTHORS
N Bunyaratavej, P Penkitti, N Kittimanon, P Boonsangsom, A Bonjongsat, S Yunoi
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Oct 2001
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Randomized pilot trial of vitamin K2 for bone loss in patients with primary biliary cirrhosis
AUTHORS
S Nishiguchi, S Shimoi, H Kurooka, A Tamori, D Habu, T Takeda, S Kubo
SPONSORS
-
CATEGORY
Bone Health
DATE
Oct 2001
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol.
AUTHORS
Inoue T, Sugiyama T, Matsubara T, Kawai S, Furukawa S
SPONSORS
Eisai Co., Ltd. (Tokyo, Japan)
CATEGORY
Bone Health
DATE
Feb 2001
KEYWORDS
bone mineral density menaquinone-4 vitamin K2
PUBMED LINK
open link icon
Link
TITLE
Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis.
AUTHORS
Shiraki M, Shiraki Y, Aoki C, Miura M
SPONSORS
-
CATEGORY
Bone Health
DATE
Mar 2000
KEYWORDS
bone mineral density menaquinone-4 osteoporosis vitamin K2
PUBMED LINK
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Link
TITLE
Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis
AUTHORS
K Yonemura, M Kimura, T Miyaji, A Hishida
SPONSORS
-
CATEGORY
Bone Health
DATE
Feb 2000
KEYWORDS
Glucocorticoids — Osteoporosis — Prednisolone — Vitamin K
PUBMED LINK
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Link
TITLE
Intake of fermented soybean (natto) increases circulating vitamin K2 (menaquinone-7) and gamma-carboxylated osteocalcin concentration in normal individuals.
AUTHORS
Tsukamoto Y, Ichise H, Kakuda H, Yamaguchi M
SPONSORS
-
CATEGORY
Bone Health
DATE
Jan 2000
KEYWORDS
menaquinone-7 natto vitamin K2
PUBMED LINK
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Link
TITLE
Interaction between vitamin K nutriture and bacterial overgrowth in hypochlorhydria induced by omeprazole
AUTHORS
S A Paiva, T E Sepe, S L Booth, M E Camilo, M E O'Brien, K W Davidson, J A Sadowski, R M Russell
SPONSORS
US Department of Agriculture, Agriculture Research Service; “Fundação de Amparo à Pesquisa do Estado de São Paulo; Gulbenkian Foundation, Lisbon
CATEGORY
Bone Health
DATE
Sep 1999
KEYWORDS
Phylloquinone, menaquinone, vitamin K status, osteocalcin, prothrombin, PIVKA-II, g-carboxyglutamic acid, urinary Gla, bacterial overgrowth, omeprazole
PUBMED LINK
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Link
TITLE
Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide
AUTHORS
Y Somekawa, M Chigughi, M Harada, T Ishibashi
SPONSORS
-
CATEGORY
Bone Health
DATE
Aug 1999
KEYWORDS
PUBMED LINK
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Link
TITLE
A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy
AUTHORS
I Iwamoto, S Kosha, S Noguchi, M Murakami, T Fujino, T Douchi, Y Nagata
SPONSORS
-
CATEGORY
Bone Health
DATE
Jan 1999
KEYWORDS
Vitamin K2; Bone mineral density; Treatment
PUBMED LINK
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Link
TITLE
Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia
AUTHORS
H Tsuji, K Honke, M Hasui
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Nov 1998
KEYWORDS
PUBMED LINK
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Link
TITLE
Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients.
AUTHORS
Sato Y, Honda Y, Kuno H, Oizumi K
SPONSORS
-
CATEGORY
Bone Health
DATE
Sep 1998
KEYWORDS
bone mineral density menaquinone-4 phylloquinone vitamin K1 vitamin K2
PUBMED LINK
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Link
TITLE
Bioavailability of phylloquinone from an intravenous lipid emulsion
AUTHORS
M E Camilo, A Jatoi, M O'Brien, K Davidson, L Sokoll, J A Sadowski, J B Mason
SPONSORS
Clinical Study Unit at the New England Medical Center; the Jean Mayer Human Nutrition Research Center on Aging at Tufts University; the Gulbenkian Foundation, Lisbon; Pharmacia and Upjohn Incorporated, Clayton, NC
CATEGORY
Metabolic Health
DATE
Apr 1998
KEYWORDS
Phylloquinone, bioavailability, lipid emulsions, vitamin K, osteolcalcin, parenteral nutrition, adults, warfarin
PUBMED LINK
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Link
TITLE
Effect of dietary fat content on oral bioavailability of menatetrenone in humans
AUTHORS
T Uematsu, S Nagashima, M Niwa, K Kohno, T Sassa, M Ishii, Y Tomono, C Yamato, M Kanamaru
SPONSORS
-
CATEGORY
Nutrition & Diet
DATE
Sep 1996
KEYWORDS
PUBMED LINK
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Link
TITLE
Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces.
AUTHORS
Nakamura K, Toyohira H, Kariyazono H, Ishibashi M, Saigenji H, Shimokawa S, Taira A
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Jan 1994
KEYWORDS
PUBMED LINK
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Link
TITLE
Vitamin K concentrations in the plasma and liver of surgical patients.
AUTHORS
Usui Y, Tanimura H, Nishimura N, Kobayashi N, Okanoue T, Ozawa K
SPONSORS
-
CATEGORY
General Preventive Health
DATE
May 1990
KEYWORDS
menaquinone phylloquinone vitamin K deficiency vitamin K1 vitamin K2
PUBMED LINK
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Link
TITLE
Dietary deficiency of phylloquinone and reduced serum levels in febrile neutropenic cancer patients.
AUTHORS
Conly J, Suttie J, Reid E, Loftson J, Ramotar K, Louie T
SPONSORS
National Cancer Institute of Canada; Eli Lilly and Company, Toronto, Ontario, Canada; Medical Research Council of Canada
CATEGORY
Nutrition & Diet
DATE
Jul 1989
KEYWORDS
menaquinone phylloquinone vitamin K deficiency vitamin K1 vitamin K2
PUBMED LINK
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Link
TITLE
Hypoprothrombinemia in febrile, neutropenic patients with cancer: association with antimicrobial suppression of intestinal microflora
AUTHORS
J M Conly, K Ramotar, H Chubb, E J Bow, T J Louie
SPONSORS
National Cancer Institute of Canada; Eli Lilly and Company
CATEGORY
General Preventive Health
DATE
Aug 1984
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma.
AUTHORS
Kimur I, Tanizaki Y, Sato S, Saito K, Takahashi K
SPONSORS
-
CATEGORY
General Preventive Health
DATE
Apr 1975
KEYWORDS
PUBMED LINK
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Link
TITLE
Effect of Vitamin K Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
AUTHORS
Hitesh Verma, Rajeev Garg
SPONSORS
-
CATEGORY
Cardiovascular Health
DATE
Jul 1905
KEYWORDS
Vitamin K; cardiometabolic risk factors; high density lipoprotein – cholesterol; menaquinones; phylloquinone; supplementation
PUBMED LINK
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Link
TITLE
Oral Consumption of Vitamin K2 for 8 Weeks Associated With Increased Maximal Cardiac Output During Exercise
AUTHORS
Brian K McFarlin, Andrea L Henning, Adam S Venable
SPONSORS
-
CATEGORY
Metabolic Health
DATE
Jul 1905
KEYWORDS
PUBMED LINK
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Link
TITLE
Efficacy of Vitamin K2 for Glucocorticoid-induced Osteoporosis in Patients with Systemic Autoimmune Diseases
AUTHORS
Kotaro Shikano, Kaichi Kaneko, Mai Kawazoe, Makoto Kaburaki, Tomoko Hasunuma, Shinichi Kawai
SPONSORS
Eisai
CATEGORY
Bone Health
DATE
Jul 1905
KEYWORDS
vitamin K2 (menatetrenone), glucocorticoid, osteoporosis, osteocalcin
PUBMED LINK
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Link
TITLE
Low-Dose Daily Intake of Vitamin K(2) (Menaquinone-7) Improves Osteocalcin γ-Carboxylation: A Double-Blind, Randomized Controlled Trials
AUTHORS
Naoko Inaba, Toshiro Sato, Takatoshi Yamashita
SPONSORS
no funding
CATEGORY
Bone Health
DATE
Jul 1905
KEYWORDS
carboxylated osteocalcin, undercarboxylated osteocalcin, blood coagulation, recommended daily intake
PUBMED LINK
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Link
TITLE
Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, double-dummy, positive drug-controlled clinical trial
AUTHORS
Yan Jiang, Zhen-Lin Zhang, Zhong-Lan Zhang, Han-Min Zhu, Yi-Yong Wu, Qun Cheng, Feng-Li Wu, Xiao-Ping Xing, Jian-Li Liu, Wei Yu, Xun-Wu Meng
SPONSORS
Eisai China Inc.; Haier Pharmaceutical Co, Ltd
CATEGORY
Hormonal & Menopause Health
DATE
Jul 1905
KEYWORDS
alfacalcidol; bone mineral density; menatetrenone; osteoporosis; postmenopausal; undercarboxylated osteocalcin
PUBMED LINK
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Link
TITLE
Postoperative use of the chemopreventive vitamin K2 analog in patients with hepatocellular carcinoma
AUTHORS
Jian-Hong Zhong, Xin-Shao Mo, Bang-De Xiang, Wei-Ping Yuan, Jin-Fang Jiang, Gui-Sheng Xie, Le-Qun Li
SPONSORS
the National Natural Science Foundation of China; Guangxi Natural Science Foundation; the Ministry of Health of Guangxi Province
CATEGORY
General Preventive Health
DATE
Jul 1905
KEYWORDS
hepatocellular carcinoma, hepatic tumor, liver tumor, postoperative, chemopreventive, vitamin, menatetrenone
PUBMED LINK
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Link
TITLE
Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone
AUTHORS
Pornpimol Rianthavorn, Kantima Pisutikul, Tawatchai Deekajorndech, Supatporn Tepmongkol, Kanya Suphapeetiporn
SPONSORS
-
CATEGORY
Bone Health
DATE
Jul 1905
KEYWORDS
alfacalcidol; bone mineral density; glucocorticoids; menatetrenone; prevention
PUBMED LINK
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Link
TITLE
Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level
AUTHORS
Mariko Ochiai, Ayumu Nakashima, Norihisa Takasugi, Kei Kiribayashi, Toru Kawai, Koji Usui, Kenichiro Shigemoto, Naoki Hamaguchi, Nobuoki Kohno, Noriaki Yorioka
SPONSORS
Japanese Association of dialysis physicians
CATEGORY
Bone Health
DATE
Jul 1905
KEYWORDS
Vitamin K2 ,Bone metabolism markers, Intact parathyroid hormone, Hemodialysis
PUBMED LINK
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Link
TITLE
Response of serum carboxylated and undercarboxylated osteocalcin to risedronate monotherapy and combined therapy with vitamin K(2) in corticosteroid-treated patients: a pilot study
AUTHORS
Takayoshi Hozuki, Tomihiro Imai, Emiko Tsuda, Akihiro Matsumura, Daisuke Yamamoto, Takanobu Toyoshima, Syuuichiro Suzuki, Rika Yamauchi, Takashi Hayashi, Shin Hisahara, Shun Shimohama
SPONSORS
Smoking Research Foundation
CATEGORY
Bone Health
DATE
Jul 1905
KEYWORDS
vitamin K2, risedronate, corticosteroid, osteocalcin, undercarboxylated osteocalcin, N-terminal telopeptide of type I collagen
PUBMED LINK
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Link
TITLE
Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporosis: a randomized prospective study
AUTHORS
Masataka Shiraki, Akira Itabashi
SPONSORS
Eisai Co. Ltd.
CATEGORY
Hormonal & Menopause Health
DATE
Jul 1905
KEYWORDS
Menatetrenone, Osteoporosis, Undercarboxylated osteocalcin, Bone turnover markers
PUBMED LINK
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Link
TITLE
Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules
AUTHORS
Tetsuo Inoue, Toshiharu Fujita, Hideaki Kishimoto, Toshitaka Makino, Tetsuro Nakamura, Toshitaka Nakamura, Tosiya Sato, Kaoru Yamazaki
SPONSORS
The Japanese Ministry of Health; Eisai Co. Ltd. (Tokyo, Japan)
CATEGORY
Bone Health
DATE
Jul 1905
KEYWORDS
Osteoporosis, Fractures, Menatetrenone, Controlled study, ADL
PUBMED LINK
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Link
TITLE
Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women
AUTHORS
Makoto Hirao, Jun Hashimoto, Wataru Ando, Takeshi Ono, Hideki Yoshikawa
SPONSORS
-
CATEGORY
Hormonal & Menopause Health
DATE
Jun 1905
KEYWORDS
alendronate, osteocalcin, postmenopausal woman, vitamin K2
PUBMED LINK
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Link
TITLE
Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG)
AUTHORS
Nobuhiro Sasaki, Eiji Kusano, Hideaki Takahashi, Yasuhiro Ando, Kazuki Yano, Eisuke Tsuda, Yasushi Asano
SPONSORS
-
CATEGORY
Bone Health
DATE
Jun 1905
KEYWORDS
Vitamin K2 (menatetrenone), Osteoprotegerin (OPG), Glucocorticoid-induced osteoporosis, Bone formation, Bone resorption
PUBMED LINK
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Link
TITLE
Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with the effect of etidronate
AUTHORS
J Iwamoto, T Takeda, S Ichimura
SPONSORS
-
CATEGORY
Hormonal & Menopause Health
DATE
Jun 1905
KEYWORDS
Menatetrenone, Etidronate, Osteoporosis, Bone mineral density (BMD), Vertebral fracture
PUBMED LINK
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Link
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