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There are 173 published clinical (human) studies on K2 according to a Pubmed search. Many of them are sponsored and published by academia bodies, not private companies.
The results of these studies are copyrighted, however quoting small sections that are directly relevant to something one is writing about is acceptable under Fair Use, as long as one provides an appropriate citation. Summarizing and quoting from a medical article in a news article (Commentary, Criticism, “transformative” purpose) is considered a fair use according to this source. All human clinical studies were designed and performed on Menaquinone-7 chemical compound which does not differ in terms of bioavailability or safety profile regardless if obtained through organic synthesis or biochemistry (industrial fermentation). Vitamin K2 offered in the market differs only in terms of purity offered and presentation oil, powder, microcapsule. We encourage all our clients to produce educational content based on the available study results and fair use policy. In case of advertising of a specific brand, use of third-party study results is prohibited.
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TITLE
Effects of vitamin K2 and D3 supplementation on epicardial adipose tissue and systemic inflammation: A substudy of the AVADEC trial
AUTHORS
Selma Hasific, Emil Johannes Ravn, Lars Melholt Rasmussen, Anna Mejldal, Damini Dey, Niels Erik Frandsen, Jes S Lindholt, Søren Auscher, Jess Lambrechtsen, Susanne Hosbond, Dilek Alan, Grazina Urbonaviciene, Søren Becker, Kristian Altern Øvrehus, Axel Diederichsen
Danish Heart Foundation; Region of Southern Denmark's Research Council; Novo Nordisk Foundation; Danish Cardiovascular Academy; Danish Heart Association; Kappa Bioscience, Norway; Orkla Care, Denmark
CATEGORY
Cardiovascular Health
DATE
Nov 2025
KEYWORDS
Atherosclerosis Cardiac CT scan Inflammation Vitamin D3 Vitamin K2
PUBMED LINK
TITLE
Effects of One-Year Menaquinone-7 Supplementation on Vascular Stiffness and Blood Pressure in Post-Menopausal Women
AUTHORS
Femke de Vries , Rudolf Bittner , Katarzyna Maresz , François Machuron , Olav Gåserød , Jean-François Jeanne , Leon J Schurgers
Gnosis by Lesaffre, Lesaffre International (formerly Nattopharma ASA, Norway)
CATEGORY
Cardiovascular Health
DATE
Feb 2025
KEYWORDS
blood pressure; post-menopause; pre/peri-menopause; vascular stiffness; vitamin k homeostasis
PUBMED LINK
TITLE
The effect of six-month oral vitamin K supplementation on calcification propensity time in individuals with type 2 diabetes mellitus: A post hoc analysis of a randomized, double-blind, placebo-controlled trial
AUTHORS
R Meer , M L Romero Prats , M G Vervloet , Y T van der Schouw , P A de Jong , J W J Beulens
ZonMW NWO-Vidi
CATEGORY
Cardiovascular Health
DATE
Jul 2024
KEYWORDS
Arterial calcification; Cardiovascular disease; Randomized controlled trial; Serum calcification propensity; Type 2 diabetes mellitus; Vitamin K.
PUBMED LINK
TITLE
Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients: A double-blind, randomized, placebo-controlled clinical trial.
AUTHORS
Eelderink C, Kremer D, Riphagen IJ, Knobbe TJ, Schurgers LJ, Pasch A, Mulder DJ, Corpeleijn E, Navis G, Bakker SJL, de Borst MH, Te Velde-Keyzer CA
Dutch Kidney Foundation (Nierstichting); Vitals Voedingssupplementen BV
CATEGORY
Cardiovascular Health
DATE
Aug 2023
KEYWORDS
arterial stiffness calcification propensity cardiovascular disease clinical research/practice kidney transplantation nephrology nutrition vascular biology vascular health vitamin K
PUBMED LINK
TITLE
Effects of vitamins K2 and D3 supplementation in patients with severe coronary artery calcification: a study protocol for a randomised controlled trial
AUTHORS
Selma Hasific, Kristian A Øvrehus, Susanne Hosbond, Jess Lambrechtsen, Preman Kumarathurai, Anna Mejldal, Emil Johannes Ravn, Lars Melholt Rasmussen, Oke Gerke, Hans Mickley, Axel Diederichsen
Kappa Bioscience, Norway and Orkla Care, Denmark
CATEGORY
Cardiovascular Health
DATE
Jul 2023
KEYWORDS
Cardiovascular imaging Clinical Trial Ischaemic heart disease NUTRITION and DIETETICS PREVENTIVE MEDICINE
PUBMED LINK
TITLE
Study protocol of the InterVitaminK trial: a Danish population-based randomised double-blinded placebo-controlled trial of the effects of vitamin K (menaquinone-7) supplementation on cardiovascular, metabolic and bone health
AUTHORS
Freja Bach Kampmann , Sanne Marie Thysen , Camilla Friis Bryde Nielsen , Klaus Fuglsang Kofoed , Lars Køber , Michael Huy Cuong Pham , Allan Vaag , Niklas Rye Jørgensen , Janne Petersen , Rikke Kart Jacobsen , Line Lund Kårhus , Axel Diederichsen , Marie Frimodt-Møller , Allan Linneberg
Bispebjerg Hospital
CATEGORY
Cardiovascular Health
DATE
May 2023
KEYWORDS
CARDIOLOGY; Calcium & bone; General endocrinology; NUTRITION & DIETETICS
PUBMED LINK
TITLE
The impact of vitamin K2 and native vitamin D supplementation on vascular calcification in pediatric patients on regular hemodialysis. A randomized controlled trial
AUTHORS
Radwa El Borolossy , Mohamed Samy El-Farsy
Ain Shams University
CATEGORY
Cardiovascular Health
DATE
Jun 2022
KEYWORDS
PUBMED LINK
TITLE
Vitamin K Intake and Atherosclerotic Cardiovascular Disease in the Danish Diet Cancer and Health Study
AUTHORS
Jamie W Bellinge , Frederik Dalgaard , Kevin Murray , Emma Connolly , Lauren C Blekkenhorst , Catherine P Bondonno , Joshua R Lewis , Marc Sim , Kevin D Croft , Gunnar Gislason , Christian Torp-Pedersen , Anne Tjønneland , Kim Overvad , Jonathan M Hodgson , Carl Schultz , Nicola P Bondonno
Danish Cancer Society, Denmark; Danish Heart Foundation and Gangstedfonden, Denmark; National Health and Medical Research Council Early Career Fellowship, Australia; National Heart Foundation of Australia Future Leader Fellowship; National Health and Medical Research Council of Australia Senior Research Fellowship; Australian Government Research Training Program Scholarship at the University of Western Australia; Australian Government Research Training Program Scholarship at Edith Cowan University; National Health and Medical Research Council of Australia; National Heart Foundation of Australia; Raine Medical Research Foundation; Healy Medical Research Foundation
CATEGORY
Cardiovascular Health
DATE
Aug 2021
KEYWORDS
atherosclerotic cardiovascular disease; dietary vitamin K; menaquinone; phylloquinone; primary prevention; prospective cohort study
PUBMED LINK
TITLE
Safety and Efficacy of Vitamin K Antagonists versus Rivaroxaban in Hemodialysis Patients with Atrial Fibrillation: A Multicenter Randomized Controlled Trial
AUTHORS
An S De Vriese , Rogier Caluwé , Hans Van Der Meersch , Koen De Boeck , Dirk De Bacquer
Onze Lieve Vrouw Hospital
CATEGORY
Cardiovascular Health
DATE
Jun 2021
KEYWORDS
cardiovascular disease; hemodialysis; randomized controlled trials
PUBMED LINK
TITLE
Identification of microbial markers across populations in early detection of colorectal cancer
AUTHORS
Yuanqi Wu, Na Jiao, Ruixin Zhu, Yida Zhang, Dingfeng Wu, An-Jun Wang, Sa Fang, Liwen Tao, Yichen Li, Sijing Cheng, Xiaosheng He, Ping Lan, Chuan Tian, Ning-Ning Liu, Lixin Zhu
National Key R&D Program of China; Guangdong Province “Pearl River Talent Plan” Innovation and Entrepreneurship Team Project; National Natural Science Foundation of China; National Postdoctoral Program for Innovative Talents of China; China Postdoctoral Science Foundation; Natural Science Foundation of Shanghai; National Key Clinical Discipline of China; Program for Young Eastern Scholar at Shanghai Institutions of Higher Learning; Fundamental Research Funds for the Central Universities; Shanghai Pujiang Program; Innovative Research Team of High‑level Local Universities in Shanghai; Medicine and Engineering Interdisciplinary Research Fund of Shanghai Jiao Tong University
CATEGORY
Cardiovascular Health
DATE
May 2021
KEYWORDS
PUBMED LINK
TITLE
Effects of vitamin K2 supplementation on atherogenic status of individuals with type 2 diabetes: a randomized controlled trial.
AUTHORS
Rahimi Sakak F, Moslehi N, Abdi H, Mirmiran P
Research Institute of Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
CATEGORY
Cardiovascular Health
DATE
May 2021
KEYWORDS
"Atherogenic index Atherogenic status Cardiovascular diseases Menaquinone-7 Type 2 diabetes Vitamin K"
PUBMED LINK
TITLE
Vitamin K Supplementation to Improve Vascular Stiffness in CKD: The K4Kidneys Randomized Controlled Trial
AUTHORS
Miles D Witham , Jennifer S Lees , Myra White , Margaret Band , Samira Bell , Donna J Chantler , Ian Ford , Roberta L Fulton , Gwen Kennedy , Roberta C Littleford , Ian V McCrea , Deborah McGlynn , Maurizio Panarelli , Maximilian R Ralston , Elaine Rutherford , Alison Severn , Nicola Thomson , Jamie P Traynor , Allan D Struthers , Kirsty Wetherall , Patrick B Mark
Tayside Academic Science Centre (NHS Tayside and University of Dundee)
CATEGORY
Cardiovascular Health
DATE
Oct 2020
KEYWORDS
arterial stiffness; chronic kidney disease; vascular calcification; vitamin K
PUBMED LINK
TITLE
Treatment to reduce vascular calcification in hemodialysis patients using vitamin K (Trevasc-HDK): A study protocol for a randomized controlled trial
AUTHORS
Sabrina-Wong-Peixin Haroon , Bee-Choo Tai , Lieng-Hsi Ling , Lynette Teo , Andrew Davenport , Leon Schurgers , Boon-Wee Teo , Priyanka Khatri , Ching-Ching Ong , Sanmay Low , Xi-Er Yeo , Jia-Neng Tan , Srinivas Subramanian , Horng-Ruey Chua , Swee-Yaw Tan , Weng-Kin Wong , Titus-Wai-Leong Lau
National University Health System, Singapore
CATEGORY
Cardiovascular Health
DATE
Sep 2020
KEYWORDS
PUBMED LINK
TITLE
Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study
AUTHORS
An S De Vriese , Rogier Caluwé , Lotte Pyfferoen , Dirk De Bacquer , Koen De Boeck , Joost Delanote , Didier De Surgeloose , Piet Van Hoenacker , Bruno Van Vlem , Francis Verbeke
Kaydence Pharma (New Brunswick, NJ, USA). Nattopharma (Lysaker, Norway)
CATEGORY
Cardiovascular Health
DATE
Jan 2020
KEYWORDS
direct oral anticoagulant; hemodialysis; oral anticoagulation; vascular calcification; vitamin K; vitamin K antagonist
PUBMED LINK
TITLE
The effect of vitamin K2 supplementation on vascular calcification in haemodialysis patients: a 1-year follow-up randomized trial
AUTHORS
Theodora Oikonomaki , Marios Papasotiriou , Theodoros Ntrinias , Christina Kalogeropoulou , Petros Zabakis , Dimitra Kalavrizioti , Ioannis Papadakis , Dimitrios S Goumenos , Evangelos Papachristou
no funding
CATEGORY
Cardiovascular Health
DATE
Nov 2019
KEYWORDS
Chronic kidney disease; Hemodialysis; Vascular calcification; Vitamin K2
PUBMED LINK
TITLE
The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial.
AUTHORS
Zwakenberg SR, de Jong PA, Bartstra JW, van Asperen R, Westerink J, de Valk H, Slart RHJA, Luurtsema G, Wolterink JM, de Borst GJ, van Herwaarden JA, van de Ree MA, Schurgers LJ, van der Schouw YT, Beulens JWJ
Dutch Heart Foundation
CATEGORY
Cardiovascular Health
DATE
Oct 2019
KEYWORDS
"cardiovascular disease diabetes menaquinone-7 vascular calcification vitamin K"
PUBMED LINK
TITLE
Effects of menaquinone-7 supplementation in patients with aortic valve calcification: study protocol for a randomised controlled trial
AUTHORS
Jes Sanddal Lindholt , Niels Erik Frandsen , Maise Høigaard Fredgart , Kristian A Øvrehus , Jordi Sanchez Dahl , Jacob Eifer Møller , Lars Folkestad , Grazina Urbonaviciene , Søren Warberg Becker , Jess Lambrechtsen , Søren Auscher , Susanne Hosbond , Dilek Hunerel Alan , Lars Melholt Rasmussen , Oke Gerke , Hans Mickley , Axel Diederichsen
Axel Diederichsen
CATEGORY
Cardiovascular Health
DATE
Aug 2018
KEYWORDS
aortic valve calcification; cardiovascular imaging; menaquinone-7; randomized clinical trial; valvular heart disease
PUBMED LINK
TITLE
High Dephosphorylated-Uncarboxylated MGP in Hemodialysis patients: risk factors and response to vitamin K(2), A pre-post intervention clinical trial.
AUTHORS
Aoun M, Makki M, Azar H, Matta H, Chelala DN
Omicron Pharmaceuticals, Lebanon
CATEGORY
Cardiovascular Health
DATE
Jun 2017
KEYWORDS
"Dephosphorylated Uncarboxylated matrix Gla protein Hemodialysis Menaquinone-7 Pre-post intervention clinical trial Vascular calcifications Vitamin K2"
PUBMED LINK
TITLE
Does statins promote vascular calcification in chronic kidney disease?
AUTHORS
Zhimin Chen , Abdul Rashid Qureshi , Paolo Parini , Eva Hurt-Camejo , Jonaz Ripsweden , Torkel B Brismar , Peter Barany , Armand M Jaminon , Leon J Schurgers , Olof Heimbürger , Bengt Lindholm , Peter Stenvinkel
Swedish Medical Research Council; Heart and Lung Foundation; Njurfonden Foundation; Westmans Foundation; Baxter Healthcare; China Scholarship Council
CATEGORY
Cardiovascular Health
DATE
Feb 2017
KEYWORDS
Chronic kidney disease; inflammation; statin; vascular calcification; vitamin K
PUBMED LINK
TITLE
Subclinical atherosclerosis is linked to small intestinal bacterial overgrowth via vitamin K2-dependent mechanisms
AUTHORS
Francesca Romana Ponziani , Maurizio Pompili , Enrico Di Stasio , Maria Assunta Zocco , Antonio Gasbarrini , Roberto Flore
-
CATEGORY
Cardiovascular Health
DATE
Feb 2017
KEYWORDS
Atherosclerosis; Cardiovascular disease risk; Dysbiosis; Small intestinal bacterial overgrowth; Vitamin K
PUBMED LINK
TITLE
Menaquinone-7 Supplementation to Reduce Vascular Calcification in Patients with Coronary Artery Disease: Rationale and Study Protocol (VitaK-CAC Trial).
AUTHORS
Vossen LM, Schurgers LJ, van Varik BJ, Kietselaer BL, Vermeer C, Meeder JG, Rahel BM, van Cauteren YJ, Hoffland GA, Rennenberg RJ, Reesink KD, de Leeuw PW, Kroon AA
Netherlands Heart Foundation, NattoPharma ASA (Hovik, Norway)
CATEGORY
Cardiovascular Health
DATE
Oct 2015
KEYWORDS
coronary artery calcification matrix gla protein menaquinone-7 vascular calcification vitamin K2
PUBMED LINK
TITLE
Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study.
AUTHORS
Caluwe R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS
NattoPharma, dieticians of the dialysis unit: Dieter Hermy, Maxim Dierkens and Marijke Van Rijsselberghe
CATEGORY
Cardiovascular Health
DATE
Jul 2014
KEYWORDS
haemodialysis menaquinone vascular calcification
PUBMED LINK
TITLE
Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial.
AUTHORS
Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJ
RWTH Aachen University
CATEGORY
Cardiovascular Health
DATE
Feb 2012
KEYWORDS
menaquinone-7 vascular calcification vitamin K deficiency vitamin K2
PUBMED LINK
TITLE
Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma
AUTHORS
Hitoshi Yoshiji, Ryuichi Noguchi, Masahisa Toyohara, Yasuhide Ikenaka, Mitsuteru Kitade, Kosuke Kaji, Masaharu Yamazaki, Junichi Yamao, Akira Mitoro, Masayoshi Sawai, Motoyuki Yoshida, Masao Fujimoto, Tatsuhiro Tsujimoto, Hideto Kawaratani, Masahito Uemura, Hiroshi Fukui
no funding
CATEGORY
Cardiovascular Health
DATE
Aug 2009
KEYWORDS
Angiogenesis; Angiotensin-converting enzyme inhibitor; Hepatocellular carcinoma; Vascular endothelial growth factor; Vitamin K2
PUBMED LINK
TITLE
Effect of Vitamin K Supplementation on Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis
AUTHORS
Hitesh Verma, Rajeev Garg
-
CATEGORY
Cardiovascular Health
DATE
Jul 1905
KEYWORDS
Vitamin K; cardiometabolic risk factors; high density lipoprotein – cholesterol; menaquinones; phylloquinone; supplementation
PUBMED LINK
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