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Supplementation Research
Aging & Longevity
Hormonal & Menopause Health
Inflammation & Immunity
Metabolic Health
General Preventive Health
Nutrition & Diet
Cardiovascular Health
Bone Health

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There are 173 published clinical (human) studies on K2 according to a Pubmed search. Many of them are sponsored and published by academia bodies, not private companies.
The results of these studies are copyrighted, however quoting small sections that are directly relevant to something one is writing about is acceptable under Fair Use, as long as one provides an appropriate citation. Summarizing and quoting from a medical article in a news article (Commentary, Criticism, “transformative” purpose) is considered a fair use according to this source. All human clinical studies were designed and performed on Menaquinone-7 chemical compound which does not differ in terms of bioavailability or safety profile regardless if obtained through organic synthesis or biochemistry (industrial fermentation). Vitamin K2 offered in the market differs only in terms of purity offered and presentation oil, powder, microcapsule. We encourage all our clients to produce educational content based on the available study results and fair use policy. In case of advertising of a specific brand, use of third-party study results is prohibited.
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TITLE
Association of vitamin intake with health-related quality of life in hemodialysis patients
AUTHORS
Ursula Alchabab, Razane El Hajj Chehade, Chloe Kharsa, Rebecca Kassab, Serena Maria Dib, Dania Chelala, Jenny Hawi, Celine Boueri, Hiba Azar, Serge Finianos, Ibrahim Abdo, Chadia Beaini, Mabel Aoun
-
CATEGORY
General Preventive Health
DATE
Oct 2024
KEYWORDS
PUBMED LINK
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Link
TITLE
The study of bioavailability and endogenous circadian rhythm of menaquinone-7, a form of vitamin K2, in healthy subjects
AUTHORS
Fan Du, Min Yan, Lili Duan, Guolong Xie, Xiuhua Yao, Wenjing Hu, Yu Liu, Min Meng, Jiepeng Chen, Di Shao
National Natural Science Foundation of China; Natural Science Foundation of Chongqing Municipal Science and Technology Bureau
CATEGORY
General Preventive Health
DATE
Dec 2023
KEYWORDS
Absorption; Bioavailability; Circadian Rhythm; Menaquinone-7
PUBMED LINK
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Link
TITLE
Inhibit progression of coronary artery calcification with vitamin K in hemodialysis patients (the iPACK-HD study): a randomized, placebo-controlled multi-center, pilot trial
AUTHORS
Rachel M Holden , Sarah L Booth , Deborah Zimmerman , Louise Moist , Patrick A Norman , Andrew G Day , Alex Menard , Xueyan Fu , M Kyla Shea , Corinne S Babiolakis , Robert Nolan , Mandy E Turner , Emilie Ward , Martin Kaufmann , Michael A Adams , Daren K Heyland
Canadian Institute for Health Research, Southeastern Ontario AHSC AFP Innovation Fund
CATEGORY
General Preventive Health
DATE
Feb 2023
KEYWORDS
chronic kidney disease; coronary artery calcification; phylloquinone; randomized pilot; vitamin K.
PUBMED LINK
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Link
TITLE
VItamin K In Peritonial Dialysis (VIKIPEDIA): Rationale and study protocol for a randomized controlled trial
AUTHORS
Stefanos Roumeliotis, Athanasios Roumeliotis, Panagiotis I Georgianos, Elias Thodis, Leon J Schurgers, Katarzyna Maresz, Theodoros Eleftheriadis, Evangelia Dounousi, Giovanni Tripepi, Francesca Mallamaci, Vassilios Liakopoulos
Aristotle University Of Thessaloniki
CATEGORY
General Preventive Health
DATE
Aug 2022
KEYWORDS
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 administration on depression status in patients with polycystic ovary syndrome: a randomized clinical trial.
AUTHORS
Tarkesh F, Namavar Jahromi B, Hejazi N, Hoseini G
Vice Chancellor of Research and Technology Department, Shiraz University of Medical Sciences (Shiraz, Iran)
CATEGORY
General Preventive Health
DATE
Jul 2022
KEYWORDS
"Depression Polycystic ovary syndrome Vitamin K2"
PUBMED LINK
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Link
TITLE
Vitamin K2 as a potential therapeutic candidate for the prevention of muscle cramps in hemodialysis patients: A prospective multicenter, randomized, controlled, crossover pilot trial
AUTHORS
Dan Xu, AnXiu Yang, Ruijun Ren, Zhong Shan, Yuan Ming Li, Jing Tan
Sungen Biotech Co., Ltd. China
CATEGORY
General Preventive Health
DATE
May 2022
KEYWORDS
Crossover trials; Hemodialysis; Muscle cramp; Safety; Vitamin K2
PUBMED LINK
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Link
TITLE
Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial.
AUTHORS
Diederichsen ACP, Lindholt JS, Moller S, Ovrehus KA, Auscher S, Lambrechtsen J, Hosbond SE, Alan DH, Urbonaviciene G, Becker SW, Fredgart MH, Hasific S, Folkestad L, Gerke O, Rasmussen LM, Moller JE, Mickley H, Dahl JS
Danish Heart Foundation; Region of Southern Denmark’s Research Council; Novo Nordisk Foundation; Kappa Bioscience, Norway; Orkla Care, Denmark
CATEGORY
General Preventive Health
DATE
May 2022
KEYWORDS
aortic valve calcification aortic valve stenosis coronary artery calcification coronary artery disease matrix Gla protein randomized controlled trial vitamin K2
PUBMED LINK
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Link
TITLE
Vitamin K2 (menaquinone-7) increases plasma adiponectin but does not affect insulin sensitivity in postmenopausal women: a randomized controlled trial.
AUTHORS
Ronn SH, Harslof T, Pedersen SB, Langdahl BL
Orkla Health; Aase and Ejnar Danielsens Foundation; Danish Osteoporosis Society; Family Hede Nielsens Foundation; Department of Endocrinology, Aarhus University Hospital Research Foundation; Central Denmark Region Research Foundation
CATEGORY
General Preventive Health
DATE
Nov 2021
KEYWORDS
insulin sensitivity menaquinone-7 postmenopausal women vitamin K2
PUBMED LINK
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Link
TITLE
The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence
AUTHORS
Kok-Yong Chin
Ministry of Education, Malaysia
CATEGORY
General Preventive Health
DATE
Apr 2020
KEYWORDS
carboxylation; cartilage; joint; menaquinone; phylloquinone
PUBMED LINK
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Link
TITLE
Circulating phylloquinone, inactive Matrix Gla protein and coronary heart disease risk: A two-sample Mendelian Randomization study
AUTHORS
Sabine R Zwakenberg , Stephen Burgess , Ivonne Sluijs , Elisabete Weiderpass ; EPIC-CVD consortium; Joline W J Beulens , Yvonne T van der Schouw
European Union Framework Programme 7; European Research Council; UK Medical Research Council; British Heart Foundation; UK National Institute for Health Research; EU Sixth Framework Programme; Medical Research Council Epidemiology Unit; European Commission (DG-SANCO); International Agency for Research on Cancer; The Dutch Heart Foundation
CATEGORY
General Preventive Health
DATE
Apr 2020
KEYWORDS
Coronary heart disease; Epidemiology; Matrix Gla protein; Mendelian randomization; Phylloquinone; Vitamin K
PUBMED LINK
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Link
TITLE
Vitamin K2 Status and Arterial Stiffness Among Untreated Migraine Patients: A Case-Control Study
AUTHORS
Anthony G Mansour , Rechdi Ahdab , Yazan Daaboul , Serge Korjian , Daniel Alexander Morrison , Essa Hariri , Maher Salem , Christelle El Khoury , Naji Riachi , Sola Aoun Bahous
Nattopharma ASA, Norway; Omicron Pharmaceuticals, Lebanon
CATEGORY
General Preventive Health
DATE
Mar 2020
KEYWORDS
arterial stiffness; matrix Gla protein; migraine; migraine with aura; pulse wave velocity; vitamin K2
PUBMED LINK
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Link
TITLE
Bicuspid Aortic Valve Stenosis and the Effect of Vitamin K2 on Calcification Using (18)F-Sodium Fluoride Positron Emission Tomography/Magnetic Resonance: The BASIK2 Rationale and Trial Design.
AUTHORS
Peeters FECM, van Mourik MJW, Meex SJR, Bucerius J, Schalla SM, Gerretsen SC, Mihl C, Dweck MR, Schurgers LJ, Wildberger JE, Crijns HJGM, Kietselaer BLJH
Stichting De Weijerhorst, Maastricht, Holandia; Health Foundation Limburg, Maastricht, Holandia
CATEGORY
General Preventive Health
DATE
Mar 2018
KEYWORDS
"18F-NaF PET/MR bicuspid aortic valve calcific aortic valve stenosis menaquinone-7 vitamin K2"
PUBMED LINK
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Link
TITLE
Vitamin K-induced effects on body fat and weight: results from a 3-year vitamin K2 intervention study.
AUTHORS
Knapen MHJ, Jardon KM, Vermeer C
NattoPharma, Høvik, Norway
CATEGORY
General Preventive Health
DATE
Jan 2018
KEYWORDS
"body fat body weight menaquinone-7 postmenopausal women vitamin K2"
PUBMED LINK
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Link
TITLE
Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study.
AUTHORS
Abdel-Rahman MS, Alkady EA, Ahmed S
-
CATEGORY
General Preventive Health
DATE
Aug 2015
KEYWORDS
DAS28-ESR Matrix metalloproteinase. Menaquinone-7 Rheumatoid arthritis ucOC
PUBMED LINK
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Link
TITLE
Antidote use in a pediatric emergency department
AUTHORS
L Martínez Sánchez , A F Almario Hernández , L Escuredo Argullós , P Maçao , V Trenchs Sainz de la Maza , C Luaces Cubells
-
CATEGORY
General Preventive Health
DATE
Oct 2014
KEYWORDS
Antidotes; Antídotos; Children; Emergency medical services; Intoxicación; Niños; Poisoning; Urgencias
PUBMED LINK
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Link
TITLE
Vitamin K status in healthy volunteers
AUTHORS
Theuwissen E, Magdeleyns EJ, Braam LA, Teunissen KJ, Knapen MH, Binnekamp IA, van Summeren MJ, Vermeer C
Nattopharma ASA (Høvik, Norway)
CATEGORY
General Preventive Health
DATE
Feb 2014
KEYWORDS
menaquinone-7 vitamin K intake vitamin K2
PUBMED LINK
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Link
TITLE
Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial
AUTHORS
Mitsuru Ishizuka , Keiichi Kubota, Mitsugi Shimoda, Junji Kita, Masato Kato, Kyung Hwa Park, Takayuki Shiraki
-
CATEGORY
General Preventive Health
DATE
Dec 2012
KEYWORDS
Des-γ-carboxy-prothrombin, disease-free survival, hepatocellular carcinoma recurrence, menatetrenone, vitamin K2 analog
PUBMED LINK
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Link
TITLE
Role of vitamin K2 in preventing the recurrence of hepatocellular carcinoma after curative treatment: a meta-analysis of randomized controlled trials
AUTHORS
Irbaz Bin Riaz , Haris Riaz, Talha Riaz, Sophia Rahman, Muhammad Amir, Maaz B Badshah, Abdul Nafey Kazi
Maastricht University Medical Center
CATEGORY
General Preventive Health
DATE
Nov 2012
KEYWORDS
Vitamin K, Hepatocellular Cancer, Hepatectomy, Chemoprevention and Recurrence
PUBMED LINK
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Link
TITLE
Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.
AUTHORS
Sato T, Schurgers LJ, Uenishi K
-
CATEGORY
General Preventive Health
DATE
Nov 2012
KEYWORDS
menaquinone-4 menaquinone-7 vitamin K2 vitamin bioavailability
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
AUTHORS
Haruhiko Yoshida, Yasushi Shiratori, Masatoshi Kudo, Shuichiro Shiina, Toshihiko Mizuta, Masamichi Kojiro, Kyosuke Yamamoto, Yukihiro Koike, Kenichi Saito, Nozomu Koyanagi, Takao Kawabe, Seiji Kawazoe, Haruhiko Kobashi, Hiroshi Kasugai, Yukio Osaki, Yasuyuki Araki, Namiki Izumi, Hiroko Oka, Kunihiko Tsuji, Joji Toyota, Toshihito Seki, Toshiya Osawa, Naohiko Masaki, Masao Ichinose, Masataka Seike, Akihisa Ishikawa, Yoshiyuki Ueno, Kazumi Tagawa, Ryoko Kuromatsu, Shotaro Sakisaka, Hiroshi Ikeda, Hidekatsu Kuroda, Hiroyuki Kokuryu, Tatsuya Yamashita, Isao Sakaida, Tetsuo Katamoto, Kentaro Kikuchi, Minoru Nomoto, Masao Omata
Eisai Co., Ltd
CATEGORY
General Preventive Health
DATE
Aug 2011
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Modelling the atypical absorption of menatetrenone and the metabolism to its epoxide: effect of VKORC1 polymorphism
AUTHORS
I H Baek, W Kang, H Y Yun, S S Lee, K I Kwon
Chungnam National University
CATEGORY
General Preventive Health
DATE
Jun 2011
KEYWORDS
genetic variations, menatetrenone, menatetrenone epoxide, VKORC1
PUBMED LINK
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Link
TITLE
Multicenter phase II trial of vitamin K(2) monotherapy and vitamin K(2) plus 1alpha-hydroxyvitamin D(3) combination therapy for low-risk myelodysplastic syndromes
AUTHORS
Nobu Akiyama, Keisuke Miyazawa, Yoshinobu Kanda, Kaoru Tohyama, Mitsuhiro Omine, Kinuko Mitani, Kazuma Ohyashiki
Esai Co., Ltd. (Tokyo, Japan); Chugai Pharmaceutical Co., Ltd. (Tokyo, Japan); Ministry of Health, Welfare and Labor of Japan
CATEGORY
General Preventive Health
DATE
Sep 2010
KEYWORDS
"Myelodysplastic syndromes Vitamin K2 Vitamin D3"
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis
AUTHORS
Kazuo Kojima, Masaya Tamano, Takashi Akima, Takashi Hashimoto, Toru Kuniyoshi, Chizu Maeda, Yuichi Majima, Koji Kusano, Toshimitu Murohisa, Makoto Iijima, Hideyuki Hiraishi
-
CATEGORY
General Preventive Health
DATE
Sep 2010
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Osteoclast inhibitory effects of vitamin K2 alone or in combination with etidronate or risedronate in patients with rheumatoid arthritis: 2-year results
AUTHORS
Minoru Morishita, Masakazu Nagashima, Koichi Wauke, Hiroshi Takahashi, Kenji Takenouchi
-
CATEGORY
General Preventive Health
DATE
Mar 2008
KEYWORDS
rheumatoid arthritis vitamin k2 etidronate risedronate receptor activator of nuclear factor-κb ligand osteoprotegerin
PUBMED LINK
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Link
TITLE
Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma
AUTHORS
Naoki Hotta, Minoru Ayada, Ken Sato, Tetsuya Ishikawa, Akihiho Okumura, Eiji Matsumoto, Tomohiko Ohashi, Shinichi Kakumu
-
CATEGORY
General Preventive Health
DATE
Oct 2007
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection
AUTHORS
Satoru Kakizaki, Naondo Sohara, Ken Sato, Hideyuki Suzuki, Masatoshi Yanagisawa, Hiroaki Nakajima, Hitoshi Takagi, Atsushi Naganuma, Toshiyuki Otsuka, Hitomi Takahashi, Tetsuya Hamada, Masatomo Mori
-
CATEGORY
General Preventive Health
DATE
Apr 2007
KEYWORDS
chemoprevention, hepatocellular carcinoma, menatetrenone, vitamin K2
PUBMED LINK
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Link
TITLE
Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population
AUTHORS
Rina Kimura, Yoshihiro Kokubo, Kotaro Miyashita, Ryoichi Otsubo, Kazuyuki Nagatsuka, Toshiho Otsuki, Toshiyuki Sakata, Junko Nagura, Akira Okayama, Kazuo Minematsu, Hiroaki Naritomi, Shigenori Honda, Kiyoshi Sato, Hitonobu Tomoike, Toshiyuki Miyata
Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO) of Japan; Ministry of Health, Labor, and Welfare of Japan; Ministry of Education, Culture, Sports, Science, and Technology of Japan
CATEGORY
General Preventive Health
DATE
Dec 2006
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Treatment of natto, a fermented soybean preparation, to prevent excessive plasma vitamin K concentrations in patients taking warfarin.
AUTHORS
Homma K, Wakana N, Suzuki Y, Nukui M, Daimatsu T, Tanaka E, Tanaka K, Koga Y, Nakajima Y, Nakazawa H
-
CATEGORY
General Preventive Health
DATE
Oct 2006
KEYWORDS
menaquinone-7 natto plasma concentration of vitamin K vitamin K2 warfarin
PUBMED LINK
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Link
TITLE
The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study
AUTHORS
Toshihiko Mizuta, Iwata Ozaki, Yuichiro Eguchi, Tsutomu Yasutake, Seiji Kawazoe, Kazuma Fujimoto, Kyosuke Yamamoto
Intractable Hepatitis Study Group of Japan awarded to K.Y
CATEGORY
General Preventive Health
DATE
Feb 2006
KEYWORDS
clinical trial, liver carcinoma, vitamin K, chemoprevention
PUBMED LINK
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Link
TITLE
Menatetrenone, a vitamin K2 analog, ameliorates cytopenia in patients with refractory anemia of myelodysplastic syndrome
AUTHORS
A Takami, H Asakura, S Nakao
-
CATEGORY
General Preventive Health
DATE
Jan 2002
KEYWORDS
Vitamin K2 · Menatetrenone · Myelodysplastic syndrome · Refractory anemia
PUBMED LINK
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Link
TITLE
Efficacy and safety of Menatetrenone-4 postmenopausal Thai women
AUTHORS
N Bunyaratavej, P Penkitti, N Kittimanon, P Boonsangsom, A Bonjongsat, S Yunoi
-
CATEGORY
General Preventive Health
DATE
Oct 2001
KEYWORDS
PUBMED LINK
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Link
TITLE
Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia
AUTHORS
H Tsuji, K Honke, M Hasui
-
CATEGORY
General Preventive Health
DATE
Nov 1998
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Anticoagulant effects of warfarin and kinetics of K vitamins in blood and feces.
AUTHORS
Nakamura K, Toyohira H, Kariyazono H, Ishibashi M, Saigenji H, Shimokawa S, Taira A
-
CATEGORY
General Preventive Health
DATE
Jan 1994
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Vitamin K concentrations in the plasma and liver of surgical patients.
AUTHORS
Usui Y, Tanimura H, Nishimura N, Kobayashi N, Okanoue T, Ozawa K
-
CATEGORY
General Preventive Health
DATE
May 1990
KEYWORDS
menaquinone phylloquinone vitamin K deficiency vitamin K1 vitamin K2
PUBMED LINK
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Link
TITLE
Hypoprothrombinemia in febrile, neutropenic patients with cancer: association with antimicrobial suppression of intestinal microflora
AUTHORS
J M Conly, K Ramotar, H Chubb, E J Bow, T J Louie
National Cancer Institute of Canada; Eli Lilly and Company
CATEGORY
General Preventive Health
DATE
Aug 1984
KEYWORDS
PUBMED LINK
open link icon
Link
TITLE
Menaquinone (vitamin K2) therapy for bronchial asthma. II. Clinical effect of menaquinone on bronchial asthma.
AUTHORS
Kimur I, Tanizaki Y, Sato S, Saito K, Takahashi K
-
CATEGORY
General Preventive Health
DATE
Apr 1975
KEYWORDS
PUBMED LINK
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Link
TITLE
Postoperative use of the chemopreventive vitamin K2 analog in patients with hepatocellular carcinoma
AUTHORS
Jian-Hong Zhong, Xin-Shao Mo, Bang-De Xiang, Wei-Ping Yuan, Jin-Fang Jiang, Gui-Sheng Xie, Le-Qun Li
the National Natural Science Foundation of China; Guangxi Natural Science Foundation; the Ministry of Health of Guangxi Province
CATEGORY
General Preventive Health
DATE
Jul 1905
KEYWORDS
hepatocellular carcinoma, hepatic tumor, liver tumor, postoperative, chemopreventive, vitamin, menatetrenone
PUBMED LINK
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Link
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